Genetic and clinical factors increasing risk for early stent thrombosis

January 01, 0001

Genetic and clinical factors increasing risk for early stent thrombosis

These French and US researchers looked at clinical and genetic factors and their relationship with early stent thrombosis. They performed a mulitcenter case-control study involving 123 patients undergoing PCI who had definite early stent thrombosis and 246 age and sex matched controls.

The researchers found: "Among the 23 genetic variants investigated in 15 different genes, the significant determinants of early stent thrombosis were CYP2C19 metabolic status (adjusted odds ratio [OR

The researchers concluded: "This case-control study identified 3 genes (CYP2C19, ABCB1, and ITGB3) and 2 clopidogrel-related factors (loading dose and proton pump inhibitors) that were independently associated with early stent thrombosis. Future studies are needed to validate the prognostic accuracy of these risk factors in prospective cohorts."

This is an important step in indentifying potential risk factors for early stent thrombosis


For the full abstract, click here.

JAMA 306(16):1765-1774, 26 October 2011 © 2011 American Medical Association
Clinical, Angiographic, and Genetic Factors Associated With Early Coronary Stent Thrombosis. Guillaume Cayla, Jean-Sébastien Hulot, Stephen A. O’Connor, et al.

Category: K. Circulatory. Keywords: early stent thrombosis, risk factors, genetic, CYP2C19, clopidogrel, case-control study, journal watch.
Synopsis edited by Dr Paul Schaefer, Toledo, Ohio. Posted on Global Family Doctor 8 November 2011

Pearls are an independent product of the Cochrane primary care group and are meant for educational use and not to guide clinical care.

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